| 摘要 |
M-nisoldipine drug intermediates acetyl isobutyl acetate synthesis method, comprising the following steps: equipped with a stirrer, thermometer, reflux condenser and dropping funnel, the reaction vessel was added 10.6 mol methyl isobutyl ether solution, 3-3.2mol methylamine solution, controlling the stirring speed 160-190rpm, increased solution temperature to 85-90 C, added dropwise 10.6-10.8mol diketene solution, keeping the reaction temperature 85--88 C, control dropwise adding time to 4-5 h, after completion of the dropwise reflux for 4 h, the reaction liquid was brown, reduced temperature of the solution to 35--40 C, washed with saline solution, dehydrating with dehydration agent, collecting 109--115C distillate in vacuum distillation, got acetyl isobutyl acetate. |
