Method of treating airway diseases with β-adrenergic inverse agonists

摘要

The use of β-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method comprises administering a therapeutically effective amount of a β-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol.

主权项

1. A method for treatment of pulmonary airway disease in a subject suffering from pulmonary airway disease comprising chronically administering a therapeutically effective amount of a β-adrenergic inverse agonist to the subject to treat the pulmonary airway disease by action of inverse agonism to promote long-term upregulation of the population of β-adrenergic receptors upon chronic administration of the β-adrenergic inverse agonist, wherein the β-adrenergic inverse agonist exhibits inverse agonist activity at the β2 receptor of bronchial tissue, wherein the β-adrenergic inverse agonist is selected from the group consisting of nadolol, bupranolol, butoxamine, carazolol, ICI-118,551, levobunolol, metoprolol, and timolol, and wherein such chronic administration requires increasing dosages over time.