发明名称 PGC-1α-modulating peptides
摘要 Peptides of general formula (I): R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp—Zq—R2 their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, a preparation process, cosmetic or pharmaceutical compositions which contain them and their use in the treatment and/or care of conditions, disorders and/or diseases which improve or are prevented by PGC-1α modulation. R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp—Zq—R2  (I)
申请公布号 US9266921(B2) 申请公布日期 2016.02.23
申请号 US201214006981 申请日期 2012.03.23
申请人 Lipotec, S.A. 发明人 García Antón José María;Almiñana Domenech Nuria;Ferrer Montiel Antonio Vicente
分类号 A61K38/00;A61K38/08;A61K38/28;A61P3/10;A61P7/12;A61P9/12;A61P25/28;C07K14/47;C07K7/06;A61K36/896;A61K38/01;A61K38/06;A61K38/07;A61K36/23;A61K36/25;A61K36/53;A61K36/736;A61K36/74 主分类号 A61K38/00
代理机构 Fay Sharpe LLP 代理人 Fay Sharpe LLP
主权项 1. A peptide of general formula (I) R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp—Zq—R2  (I) its stereoisomers, mixtures thereof and/or its cosmetic or pharmaceutical acceptable salts, wherein: AA1 is selected from the group consisting of -His- and -Ser-; AA2 is selected from the group consisting of -Ile- and -Val-; AA3 is selected from the group consisting of -Tyr- and -Val-, AA4 is -Val-; AA5 is selected from the group consisting of -Ala-, -Arg- and -Gly-; AA6 is selected from the group consisting of -Thr- and -Val-; W, X, Y and Z are amino acids and are independently selected from amongst themselves; n, m, p and q are independently selected from amongst themselves and have a value of 0 or 1; n+m+p+q is lower or equal to 2; R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO—, wherein R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl, and substituted or unsubstituted heteroarylalkyl; R2 is selected from the group consisting of —NR3R4, —OR3 and —SR3, wherein R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl; and on condition that R1 and R2 are not α-amino acids.
地址 Gava, Barcelona ES