发明名称 |
METHOD FOR MANUFACTURING LACTIC ACID-GLYCOLIC ACID COPOLYMER AND METHOD FOR MANUFACTURING SALT THEREOF |
摘要 |
An object of the invention is to produce a purified lactic acid-glycolic acid copolymer, preferably in the form of powder, having a reduced content of dimers such as residual lactide and glycolide by a simple industrial process without the use of any high-shear special device. Another object of the invention is to realize industrial simple production of a high-purity lactic acid-glycolic acid copolymer which has small amounts of dimers such as residual lactide and glycolide and small amounts of a low-molecular weight lactic acid-glycolic acid copolymer or a salt thereof and which has a small ratio of weight average molecular weight to number average molecular weight (Mw/Mn). In the invention, a purified lactic acid-glycolic acid copolymer (A2) or a salt thereof is produced by a process including the steps of (1-1) dissolving a lactic acid-glycolic acid copolymer (A1) containing lactic acid units and glycolic acid units or a salt thereof into at least one organic solvent (B1) having a solubility at 25°C of not less than 1 wt% to prepare a solution of the lactic acid-glycolic acid copolymer (A1) or the salt thereof; (1-2) adding at least one solvent (S1) selected from water and aliphatic alcohols (B2) to the solution of the lactic acid-glycolic acid copolymer (A1) or the salt thereof to prepare a mixture liquid including the lactic acid-glycolic acid copolymer (A1) or the salt thereof; (2) adding the mixture liquid prepared in the step (1-2) to a solvent (S2') including at least one selected from water and aliphatic alcohols (B2) to precipitate a purified lactic acid-glycolic acid (A2) or a salt thereof; and (3) recovering the precipitate of the purified lactic acid-glycolic acid copolymer (A2) or the salt thereof. |
申请公布号 |
EP2985304(A1) |
申请公布日期 |
2016.02.17 |
申请号 |
EP20140783514 |
申请日期 |
2014.04.08 |
申请人 |
MITSUI CHEMICALS, INC. |
发明人 |
NAGAHARA, KIYOTERU;FUKUIRI, YASUSHI;KAWABATA, TOMOYUKI |
分类号 |
C08G63/90;A61K47/34;C08G63/06 |
主分类号 |
C08G63/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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