| 摘要 |
There is provided a topical pharmaceutical composition comprising the following components and percentages: ester of salicylic or nicotinic acid - 10-20%; menthol - 5-10%; lower alcohol - 15-35%; water - 10-20%; propylene glycol and/or pentane-1,5-diol - 15-35%; hydrophilic pharmaceutically-acceptable non-volatile non-solvent for menthol - 2-16%; and, optionally, up to 5% camphor, all percentages being by weight. Also provided is a topical pharmaceutical composition comprising a volatile phase and a non-volatile phase, the non- volatile phase comprising from 32-81% of the total composition by weight, and comprising the following non-volatile constituents, expressed as % weight of the non-volatile phase: ester of salicylic or nicotinic acid - 14-48 %; menthol - 7-27 %; propylene glycol and/or pentane-1,5-diol - 25-67 %; hydrophilic pharmaceutically-acceptable non-volatile non- solvent for menthol - 3-35 %, and a concentrate comprising the non-volatile components of this composition. The compositions are useful in the treatment or prevention of pain. |
