Lipoyl compounds and their use for treating ischemic injury

摘要

The disclosure relates to a family of compounds as shown in Formula (I), wherein X can either be absent of an amino acid and R and R’are as disclosed in the specification. The disclosure also relates to a method of using these lipoyl compounds in the treatment of ischemic injury or ischemia-reperfusion injury. Examples of these compounds include: N-(R)-lipoyl-L-glutamyl-L-alanine N-(R)-lipoyl-3-aminobenzenesulfonic acid N-(R)-lipoyl-aminoethylphosponic acid N-(R)-lipoyliminodiacetic acid N-(R)-lipoyl-L-4-carboxyphenylalanine