发明名称 |
4-METHYLUMBELLIFERONE TREATMENT FOR IMMUNE MODULATION |
摘要 |
Compositions for treating autoimmune, allergic, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier are described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. Methods for treating autoimmune diabetes, multiple sclerosis and/or autoimmune demyelination, including administering to the subject a composition having a compound in an amount effective to inhibit hyaluronan synthesis in a mammalian subject, are also described. |
申请公布号 |
WO2015023691(A2) |
申请公布日期 |
2015.02.19 |
申请号 |
WO2014US50770 |
申请日期 |
2014.08.12 |
申请人 |
BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BOLLYKY, PAUL;NAGY, NADINE;WIGHT, THOMAS;KUIPERS, HEDWICH, F. |
分类号 |
A61K31/122 |
主分类号 |
A61K31/122 |
代理机构 |
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