| 发明名称 |
LAMBODIES WITH HIGH AFFINITY AND SELECTIVITY FOR GLYCANS AND USES THEREFOR |
| 摘要 |
The invention relates to dimeric proteins comprised of subunits having (i) recombinant lamprey variable lymphocyte receptor (VLR) diversity regions linked to (ii) multimerization domains. The dimeric proteins exhibit binding specificity for glycosylated antigens, and they may be used in methods of detecting or isolating glycans from a sample, and in methods of disease diagnosis, prognosis, progression monitoring, treatment, and imaging. |
| 申请公布号 |
US2014322825(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201214359653 |
申请日期 |
2012.11.21 |
| 申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
Pancer Zeev;Mao Li;Hong Xia;Ma Zhi-Qing |
| 分类号 |
G01N33/566 |
主分类号 |
G01N33/566 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A lambody, wherein the lambody comprises two lambody subunits dimerized via their multimerization domains. |
| 地址 |
Baltimore MD US |
