发明名称 |
Modulation of signal transducer and activator of transcription 3 (STAT3)expression |
摘要 |
Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases. |
申请公布号 |
US8816056(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US201213436558 |
申请日期 |
2012.03.30 |
申请人 |
Isis Pharmaceuticals, Inc. |
发明人 |
Swayze Eric E.;Freier Susan M.;MacLeod Robert A.;Kim Youngsoo |
分类号 |
C07H21/02;C07H21/04;C12N15/11;C12N15/113;C12N15/00 |
主分类号 |
C07H21/02 |
代理机构 |
|
代理人 |
Barrett Rebecca |
主权项 |
1. A compound comprising a single-stranded modified oligonucleotide consisting of 16 linked nucleosides having a nucleobase sequence consisting of the sequence of SEQ ID NO: 245, or a pharmaceutically acceptable salt thereof, wherein the modified oligonucleotide comprises:
a gap segment consisting of ten linked deoxynucleosides; a 5′ wing segment consisting of 3 linked nucleosides; and a 3′ wing segment consisting of 3 linked nucleosides; wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment; wherein each nucleoside of each wing segment comprises a constrained ethyl nucleoside; wherein each internucleoside linkage of the modified oligonucleotide is a phosphorothioate linkage; and wherein each cytosine of the modified oligonucleotide is a 5 ′-methylcytosine. |
地址 |
Carlsbad CA US |