| 发明名称 |
2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS |
| 摘要 |
<p>The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.</p> |
| 申请公布号 |
KR20120104598(A) |
申请公布日期 |
2012.09.21 |
| 申请号 |
KR20127017919 |
申请日期 |
2010.12.06 |
| 申请人 |
SIENA BIOTECH S.P.A.;F. HOFFMANN-LA ROCHE AG |
发明人 |
BANNER DAVID;GUBA WOLFGANG;HILPERT HANS;MAUSER HARALD;MAYWEG ALEXANDER V.;NARQUIZIAN ROBERT;PINARD EMMANUEL;POWER EOIN;ROGERS EVANS MARK;WOLTERING THOMAS;WOSTL WOLFGANG |
| 分类号 |
C07D413/12;A61K31/5355;A61P3/10;A61P25/00 |
主分类号 |
C07D413/12 |
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