PROCESS FOR ENANTIOSEPARATION OF CHIRAL SYSTEMS WITH COMPOUND FORMATION USING TWO SUBSEQUENT CRYSTALLIZATION STEPS
摘要
Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, in the 3-phase region (20) of the ternary phase diagram of chiral compound forming systems to achieve the establishment of the solid/liquid phase equilibria; phase-separating the liquid and solid phase formed by the placing step; shifting the eutectic composition of the remaining liquid towards a lower eutectic composition (xE) until the overall composition is located in the 2-phase region (15) of the ternary phase diagram of chiral compound forming systems; and performing crystallisation in the 2-phase region (10) of the ternary phase diagram for obtaining the target enantiomer in the solid phase. In some cases the shifting step can be skipped.
申请公布号
WO2010025968(A3)
申请公布日期
2010.05.14
申请号
WO2009EP57562
申请日期
2009.06.18
申请人
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V.;LORENZ, HEIKE;KAEMMERER, HENNING;POLENSKE, DANIEL;SEIDEL-MORGENSTERN, ANDREAS
发明人
LORENZ, HEIKE;KAEMMERER, HENNING;POLENSKE, DANIEL;SEIDEL-MORGENSTERN, ANDREAS