发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION WITH CONJUGATED ANTIBODIES OR ANTIBODY FRAGMENTS |
摘要 |
The present invention concerns methods and compositions for treatment of HIV infection in a subject. The compositions may comprise a targeting molecule against an HIV antigen, such as an anti-HIV antibody or antibody fragment. The anti-HIV antibody or fragment may be conjugated to a variety of cytotoxic agents, such as doxorubicin. In a preferred embodiment, the antibody or fragment is P4/D10. Other embodiments may concern methods of imaging, detection or diagnosis of HIV infection in a subject using an anti-HIV antibody or fragment conjugated to a diagnostic agent. In alternative embodiments, a bispecific antibody with at least one binding site for an HIV antigen and at least one binding site for a carrier molecule may be administered, optionally followed by a clearing agent, followed by administration of a carrier molecule conjugated to a therapeutic agent. |
申请公布号 |
EP2016173(A2) |
申请公布日期 |
2009.01.21 |
申请号 |
EP20070761994 |
申请日期 |
2007.05.08 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOLDENBERG, DAVID, M.;CHANG, CHIEN, HSING;ROSSI, EDMUND, A.;MCBRIDE, WILLIAM, J. |
分类号 |
C12N7/00 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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