UREA DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTIVIRAL COMPOSITION CONTAINING THE SAME

摘要

Urea derivatives are provided to inhibit the growth of virus, especially coronavirus strongly. An antiviral composition comprising the urea derivatives is also provided to treat diseases caused by coronavirus including SARS(severe acute respiratory syndrome). The urea derivatives represented by the formula(1) or pharmaceutically acceptable salts thereof are prepared by reacting compounds represented by the formula(2) with compounds represented by the formula(3) at 0-25 deg. C, wherein R^1 is C1-C4 alkyl group, C1-C2 alkyl carbonyl group, C1-C2 alkoxy carbonyl group, C1-C2 hydroxyalkyl group or carboxyl group; R^2 is C1-C4 alkyl group; R^3 and R^4 are each independently C1-C4 alkyl group or C1-C4 alkoxy group; and n is an integer from 1 to 3. Further, the C1-C4 alkyl group is methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl or sec-butyl.