发明名称 |
MORPHOLINOBILDGEBUNG UND THERAPIE |
摘要 |
The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the targeting moiety selectively binds to a primary, target-specific binding site of the target site or to a substance produced by or associated with the target site; (b) optionally, a clearing agent; and (c) a second conjugate comprising a complementary Morpholino oligomer and a diagnostic agent or therapeutic agent. The method comprises administering (a), optionally (b), and (c) to a mammal. |
申请公布号 |
DE60213771(D1) |
申请公布日期 |
2006.09.21 |
申请号 |
DE2002613771 |
申请日期 |
2002.04.01 |
申请人 |
THE UNIVERSITY OF MASSACHUSETTS |
发明人 |
HNATOWICH, J.;RUSCKOWSKI, MARY;LIU, GUOZHENG |
分类号 |
A61K51/04;A61B5/055;A61K;A61K31/535;A61K39/395;A61K41/00;A61K45/00;A61K47/48;A61K49/08;A61K51/00;A61K51/10;A61P35/04;C07K16/30;C12P21/08;C12Q1/68 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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