发明名称 |
Process for the isolation and purification of HMG-CoA reductase inhibitors |
摘要 |
<p>A process for the isolation and purification of HMG-CoA reductase inhibitors from a mycelium biomass is described, which comprises: clarifying a mycelium broth and concentrating the clarified broth to a lower volume, acidifying of the concentrate to a pH value in the range of 4.5 to 7.5, followed by extracting the HMG-CoA reductase inhibitor with ethyl acetate, crystallization of the HMG-CoA reductase inhibitor from a water-miscible or water-soluble organic solvent, and crystallization of the HMG-CoA reductase inhibitor from an organic solvent having limited miscibility or solubility with water. The crystallization steps may also be reverse. The concept of a combination of the specified crystallization steps can also be used for the purification of a crude HMG-CoA reductase inhibitor.</p> |
申请公布号 |
SK285074(B6) |
申请公布日期 |
2006.05.04 |
申请号 |
SK20000001185 |
申请日期 |
1999.02.17 |
申请人 |
LEK PHARMACEUTICAL AND CHEMICAL COMPANY D. D. |
发明人 |
PFLAUM ZLATKO;MILIVOJEVIC DUSAN;SENICA DAVID |
分类号 |
C12N9/99;A61K31/22;A61K31/351;A61K31/352;A61K31/366;A61P3/06;A61P9/12;A61P43/00;B01D9/02;B01D11/02;B01D15/08;B01D37/00;B01F1/00;C07D309/30;C12P;C12P7/40;C12P7/42;C12P7/62;C12P17/06;C12R1/00 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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