Cycloalkylene amide compounds as NR2B receptor antagonists

摘要

This invention provides a compound of the formula (I): wherein R<1 >represents wherein R<5 >represents a hydroxy group or the like; R<6 >and R<7 >independently represents a hydrogen atom or the like: V represents an alkylene or the like: W represents a carbon atom or the like: Z represents a carbon or the like: R<2 >represents a hydrogen atom or the like: R<3 >represents a hydrogen or the like: A represents a cycloalkylene or the like: X represents a covalent bond or the like: R<4 >represents an aryl or the like. These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.