| 摘要 |
A novel class of non-RGD disintegrins is described. These disintegrins have the core sequence KTS, and selectively inhibit the binding of alpha1beta1 integrin to its adhesive ligands. Two KTS-disintegrins, obtustatin and viperisrastatin, are also described. KTS-disintegrins can be used to treat diseases and modulate biological conditions associated with alpha1beta1 integrin.
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