发明名称 |
Polyurea-based fabric glue |
摘要 |
The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time. |
申请公布号 |
US9404026(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201514703270 |
申请日期 |
2015.05.04 |
申请人 |
Adhesys Medical GmbH |
发明人 |
Heckroth Heike;Nefzger Hartmut;Eggert Christoph |
分类号 |
C08L75/02;C08L75/04;C09D175/02;C08G18/10;C09J175/02;A61L24/04 |
主分类号 |
C08L75/02 |
代理机构 |
Drinker Biddle & Reath LLP |
代理人 |
Drinker Biddle & Reath LLP |
主权项 |
1. A tissue adhesive composition comprising a polyurea system comprising
A) isocyanate-functional prepolymers obtained by reacting
aliphatic isocyanates A1) withpolyols A2) comprising polyester polyols and/or polyester-polyether polyols and/or polyether polyols, which have a number-average molecular weight of ≧400 g/mol, an average OH functionality of 2 to 6, and 60% to 90% of ethylene oxide-based units, based on the amounts of alkylene oxide units that are present in total, B) amino-functional aspartic esters of formula (I) wherein
X is an organic radical containing no Zerewitinoff-active hydrogen,R1 and R2 are identical or different organic radicals containing no Zerewitinoff-active hydrogen, andn is an integer of at least 2,and/or optionally C) organic fillers and optionally D) reaction products of the isocyanate-functional prepolymers of A) with aspartic esters B) and/or organic fillers C), wherein said system comprises water and/or tertiary amine as E), and wherein the system when cured has no cytotoxicity in accordance with ISO 10993. |
地址 |
Aachen DE |