发明名称 Polyurea-based fabric glue
摘要 The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.
申请公布号 US9404026(B2) 申请公布日期 2016.08.02
申请号 US201514703270 申请日期 2015.05.04
申请人 Adhesys Medical GmbH 发明人 Heckroth Heike;Nefzger Hartmut;Eggert Christoph
分类号 C08L75/02;C08L75/04;C09D175/02;C08G18/10;C09J175/02;A61L24/04 主分类号 C08L75/02
代理机构 Drinker Biddle & Reath LLP 代理人 Drinker Biddle & Reath LLP
主权项 1. A tissue adhesive composition comprising a polyurea system comprising A) isocyanate-functional prepolymers obtained by reacting aliphatic isocyanates A1) withpolyols A2) comprising polyester polyols and/or polyester-polyether polyols and/or polyether polyols, which have a number-average molecular weight of ≧400 g/mol, an average OH functionality of 2 to 6, and 60% to 90% of ethylene oxide-based units, based on the amounts of alkylene oxide units that are present in total, B) amino-functional aspartic esters of formula (I) wherein X is an organic radical containing no Zerewitinoff-active hydrogen,R1 and R2 are identical or different organic radicals containing no Zerewitinoff-active hydrogen, andn is an integer of at least 2,and/or optionally C) organic fillers and optionally D) reaction products of the isocyanate-functional prepolymers of A) with aspartic esters B) and/or organic fillers C), wherein said system comprises water and/or tertiary amine as E), and wherein the system when cured has no cytotoxicity in accordance with ISO 10993.
地址 Aachen DE