| 摘要 |
<p>The present invention describes a novel interaction between Smad6 and the Hox genes in nuclear transcriptional regulation following BMP signal transduction. The accompanying figure shows interaction between flag-tagged, recombinant Smad6 and Hoxc-8 in the presence and absence of bone morphogenetic protein type IA receptor, ALK3. The present invention further provides methods of using this novel Smad6/Hox protein interaction, thereby resulting in expression of a Hox protein-repressed gene and/or stimulating bone formation.</p> |
