Compositions and methods for increasing the bioavailability of lactone ring containing drugs

摘要

Compositions and methods are described for increasing the bioavailability of drugs, and in particular, drugs and prodrugs containing lactone structures which are hydrolyzed to open forms (carboxylic acids and alcohols) by serum and tissue paraoxonase. Inhibitors of paraoxonase (e.g. lactams) are co-administered with such drugs, thereby preventing paraoxonase from acting on these lactone substrates. Such inhibitors are particularly suitable in conjunction with the administration of lovastatin, simvastatin or mevastatin.