Methods for the preparation of novel sidechain-bearing taxanes and intermediates
摘要
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
申请公布号
US6090951(A)
申请公布日期
2000.07.18
申请号
US19970917158
申请日期
1997.08.25
申请人
POSS, MICHAEL A.;MONIOT, JEROME L.;TRIFUNOVICH, IVAN D.;KUCERA, DAVID J.;THOTTAHIL, JOHN K.;CHEN, SHU-HUI;WEI, JIANMEI
发明人
POSS, MICHAEL A.;MONIOT, JEROME L.;TRIFUNOVICH, IVAN D.;KUCERA, DAVID J.;THOTTAHIL, JOHN K.;CHEN, SHU-HUI;WEI, JIANMEI