发明名称 |
Use of nucleic acid for preparing a medicament for gene therapy that is injected in striped musculature |
摘要 |
<p>The invention provides a method of transferring in vivo a molecule into a striated muscle cell. More specifically, a method of the invention comprises contacting in vivo a striated muscle cell with a molecule, and electrically stimulating the muscle cell with one or more unipolar pulses of an electric field intensity ranging from 1 to 800 V/cm<SUP>2</SUP>. In one embodiment, the molecule is a nucleic acid encoding a protein of interest. For example, the invention provides methods of promoting angiogenesis and hemostasis.</p> |
申请公布号 |
CZ9904755(A3) |
申请公布日期 |
2000.07.12 |
申请号 |
CZ19990004755 |
申请日期 |
1998.06.30 |
申请人 |
RHONE-POULENC RORER S. A.;INSTITUT GUSTAVE ROUSSY;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
BUREAU MICHEL;MIR LLUIS;SCHERMAN DANIEL |
分类号 |
A61K31/711;A61K38/22;A61K39/00;A61K48/00;A61N1/32;A61P43/00;C12N5/08;(IPC1-7):A61K48/00 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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