| 摘要 |
PURPOSE: Provided is anticonvulsant derivatives useful in treating obesity. CONSTITUTION: A method for treating obesity comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of the formula I: wherein X is CH2 or oxygen; R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are independently hydrogen or lower alkyl and, when X is oxygen, R2 and R3 and/or R4 and Rs together may be a methylenedioxy group. The compound of formula I is topiramate. The therapeutically effective amount is of from about 50 to 400 mg.
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