发明名称 |
SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION |
摘要 |
<p>A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (III), wherein n is a number selected from 0, 1 and 2; wherein R<6> is selected from hydrido and halo; wherein R<7> is selected from hydrido and halo; wherein R<8> is selected from hydrido, halo, lower alkyl, lower alkoxy, lower haloalkyl, lower haloalkoxy, and hydroxyl; wherein R<9> is selected from hydrido, halo, and lower alkyl; or wherein R<8> and R<9> together form methylenedioxy; and wherein R<11> is selected from lower alkyl and amino; or a pharmaceutically-acceptable salt thereof.</p> |
申请公布号 |
GR3030810(T3) |
申请公布日期 |
1999.11.30 |
申请号 |
GR19990401898T |
申请日期 |
1999.07.20 |
申请人 |
G.D. SEARLE & CO. |
发明人 |
REITZ, DAVID, B.;MANNING, ROBERT, E.;HUANG, HORNG-CHI;LI, JINGLIN |
分类号 |
A61K31/10;A61K31/18;A61K31/357;A61K31/36;A61K31/44;A61P29/00;A61P43/00;C07C13/28;C07C25/18;C07C35/21;C07C43/20;C07C311/16;C07C311/29;C07C317/14;C07C317/22;C07C323/65;C07D213/34;C07D213/57;C07D213/61;C07D213/64;C07D213/65;C07D213/70;C07D213/71;C07D317/56;(IPC1-7):C07C317/14;C07D213/52;C07D213/56 |
主分类号 |
A61K31/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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