INSULIN C-PEPTIDES

摘要

The present invention relates to a peptide being a fragment of the human insulin C-peptide, said peptide comprising the sequence ELGGGPGAG or a fragment thereof, or the sequence EGSLQ or a fragment thereof, and having the ability to stimulate Na+K+ATPase activity. Further provided are biomimetic organic compounds exhibiting activation of Na+K+ATPase activity and/or cellular binding to renal tubule cells and fibroblasts at at least the level exhibited by the aforementioned peptides or their fragments. Such peptides and compounds have utility in combatting diabetes and diabetic complications, or for stimulating Na+K+ATPase activity.