发明名称 |
ARTIFICIAL RHEUMATIC PANNUS TISSUES AND DIAGNOSTIC METHOD FOR DETECTING RHEUMATOID ARTHRITIS |
摘要 |
The invention concerns rheumatic pannus tissue which forms pannus-type villi and preferably contains class II HLA positive macrophage-type cells and vimentin-producing fibroblast-type cells. The invention also concerns a process for preparing rheumatic pannus tissue, and the use of rheumatic pannus tissue for discovering pharmacologically effective substances. The invention further concerns a method and diagnostic procedure for the in vitro diagnosis of rheumatoid arthritis, which method is characterized in that the absence of or reduction in the number of CD21 on B-cells in the synovial fluid is detected. |
申请公布号 |
WO9806825(A1) |
申请公布日期 |
1998.02.19 |
申请号 |
WO1997EP04308 |
申请日期 |
1997.08.07 |
申请人 |
KLINIKUM DER ALBERT-LUDWIGS-UNIVERSITAET FREIBURG;ILLGES, HARALD;MELCHERS, INGA |
发明人 |
ILLGES, HARALD;MELCHERS, INGA |
分类号 |
C12N5/077;G01N33/564;G01N33/68 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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