发明名称 |
A CANCER ASSOCIATED GENE, TESTIS-ASSOCIATED HELICAA CANCER ASSOCIATED GENE, TESTIS-ASSOCIATED HELICASE (TAH), PROTEIN EXPRESSED THEREFROM AND USES THESE (TAH), PROTEIN EXPRESSED THEREFROM AND USES THEREOF REOF |
摘要 |
We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer. |
申请公布号 |
WO9621021(A3) |
申请公布日期 |
1996.12.19 |
申请号 |
WO1995US16978 |
申请日期 |
1995.12.28 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
CHEN, LAN, BO;BAO, SHIDENG |
分类号 |
A61K38/00;C12N9/90;G01N33/50 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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