ISOLATED P27 PROTEIN AND ITS ENCODING NUCLEIC ACID MOLECULES

摘要

The subject invention provides an isolated protein having an apparent molecu lar weight of about 27 kD and capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. The subject invention also provides the nucleic acid encoding the p27 protein, vectors, and host cells for producing the recombinant form of the p27 protein. The su bject invention further provides methods for identifying agents capable of modulating the ability of p27 to inhibit the activation of the cy clin E-Cdk2 complex. Finally, the subject invention prov ides methods for treating subjects diagnosed with hypoproliferative disorders usi ng said agents.