PROCESS FOR THE PREPARATION OF POROUS POLYACRYLONITRILE POLYMER BEADS

摘要

30,987 PROCESS FOR THE PREPARATION OF POROUS POLYMER BEADS Isotropic porous polymer beads having a high controllable surface porosity and large pore diameters from about 0.002 to about 5 microns are produced from solutions of an acrylonitrile polymer or a copolymer by a thermally-induced phase separation process including intensively shearing the polymer solution into small droplets. The use of mixed solvent non-solvent combinations as solvents for the polymers, and preferably reducing the polymer content in solution to below 10 percent produces high pore content, substantially spherical beads having a morphology ideally suited to the chromatography of large molecules, such as proteins, and for enzyme-binding.