| 摘要 |
NEW MATERIAL:The compound of formula I or formula II [R<1> is (protected) amino; R<2> is organic residue bonded to C atom; R<3> is residue obtained by removing alpha-amino group from optically active alpha-amino acid or its derivative]. EXAMPLE:(3S,4R)-1-[( 1S )-( 1-methoxycarboynl-2-methyl )propyl]-3-phthalimido-4- sty-ryl-2-azetidinone. USE:A synthetic intermediate of beta-lactam antibiotic. PREPARATION:The substituted acetic acid of formula R<1>' CH2COOH (R<1>' is protected amino)or its reactive derivative at the COOH group is made to react with the substituted methyleneamine compound of formula R<2>CH=NR<3>, and if necessary, the protective group is removed from the reaction product. |
