摘要 |
PURPOSE:The titled reactive polymer useful in the production of a radioactive metal-bound radiodiagnostic agent for nuclear-medical applications for detection of a particular disease, comprising a specified polysuccinimide derivative. CONSTITUTION:A polysuccinimide of formula I (wherein k is a natural number) is reacted with an amino group-containing bifunctional ligand compound, a compound of formula II (wherein W is a lower alkylene, Z is H or a group which forms, together with the adjacent S, an active disulfide, and which, when Z is H, may form together with another -SH, an intramolecular or intermolecular -S-S- bond in equilibrium, these are covered by -SH), and optionally, a water-soluble aliphatic amine to obtain a polysuccinimide derivative having an MW (in terms of globular protein) of 2,000-1,000,000 and represented by formula III (wherein X is the residue of component B, Y is a water-soluble aliphatic prim. amine residue, n, m, l, r, p, and q are each 0 or a natural number representing the number of repeating units, m+n>=2, and 0.001<=p+q/n+m+l+r+p+q<=0.50).
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