| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate raw material especially for anti-inflammatory analgesic economically and readily, by using readily obtainable 2-nitro-3,4-dichloro-trifluoromethyl-toluene as a raw material and reacting the compound in the presence of a basic compound and a hydrogenating catalyst. CONSTITUTION:2-Nitro-3,4-dichloro-6-trifluoromethyl-toluene is used as a raw material and reacted in the presence of a basic substance such as sodium hydroxide, trimethylamine, etc., at about 0-150 deg.C, preferably 80-120 deg.C at 1-20kg/cm<2>, preferably 6-10kg/cm<2> and the nitro group is hydrogenated and dechlorinated to give the aimed compound. Palladium supported on active carbon is especially preferable as the hydrogenating catalyst and the concentration of the catalyst is preferably about 1-5wt% based on the raw material compound. The raw material compound is obtained by nitrating 3,4-dichloro-6-trifluoromethyltoluene. |
