发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV NYA BICYKLISKA FOERENINGAR |
摘要 |
<p>Bicyclic compounds of the general formula (I), <IMAGE> wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared in such a way that a) a compound of the general formula (V), <IMAGE> wherein Y<1> and Y<2> are as defined above and R' is a removable amido protecting group other than phenyl group, is activated on the carboxy group and then reacted with a salt of a malonic acid hemiester, wherein the alcohol component is a C1-5 aliphatic alcohol or a substituted benzyl alcohol, the resulting new compound of the general formula (IV), <IMAGE> wherein R', Q, Y<1> and Y<2> are as defined above, is reacted with a sulfonic azide in the presence of a tertiary amine, or b) a compound of the general formula (V) is activated on its carboxy group and reacted then with a diazoacetic acid ester, thereafter the R' protecting group of a resulting new compound of the general formula (III> <IMAGE> is removed, and the resulting compound of the general formula (II> <IMAGE> is subjected to ring closure to form the desired end-product.</p> |
申请公布号 |
FI824521(A0) |
申请公布日期 |
1982.12.30 |
申请号 |
FI19820004521 |
申请日期 |
1982.12.30 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T |
发明人 |
LEMPERT, KAROLY;DOLESCHALL, GABOR;FETTER, JOZSEF;HORNYAK, GYULA;HUSZTHY, PETER;NYITRAI, JOZSEF;SIMIG, GYULA;ZAUER, KAROLY;GIZUR, TIBOR;HARSANYI, KALMAN;FEKETE, GYOERGY;SZPORNY, LASZLO;HAJOS, GYOERGY |
分类号 |
A61K31/397;A61K31/40;A61P31/04;B01J31/00;C07D205/08;C07D207/26;C07D207/277;C07D405/04;C07D411/04;C07D477/00;C07D477/04;(IPC1-7):C07D/ |
主分类号 |
A61K31/397 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|