发明名称 |
METHOD FOR SCREENING COMPOUNDS CAPABLE OF INHIBITING FIXING BETWEEN THE TRANSCRIPTION FACTOR OF STAT1 AND THE TRANSCRIPTION FACTOR OF USF1 |
摘要 |
The invention concerns a method for determining whether a candidate compound is capable of inhibiting fixing between STAT1 and USF1 polypeptides comprising the following steps: (a) provide all or part of the STAT1 polypeptide capable of fixing with the USF1 polypeptide; (b) providing all or part of the USF1 polypeptide capable of fixing with the STAT1 polypeptide; (c) contacting said polypeptides as defined in (a) and (b) with one said candidate compound in conditions suitable for fixing between the STAT1 and USF1 polypeptides; (d) measuring the fixing between the STAT1 and USF1 polypeptides; and (e) comparing said measurement with the fixing measurement between STAT1 and USF1 polypeptides in similar experimental conditions in the absence of said candidate compound, a decrease in fixing leading to conclude that said compound candidate is capable of inhibiting fixing between STAT1 and USF1 polypeptides.
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申请公布号 |
WO9942571(A1) |
申请公布日期 |
1999.08.26 |
申请号 |
WO1999FR00376 |
申请日期 |
1999.02.19 |
申请人 |
NOVIMMUNE S.A.;MACH, BERNARD |
发明人 |
MACH, BERNARD |
分类号 |
C12N15/09;C07K14/47;C12Q1/02;C12Q1/68;(IPC1-7):C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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