摘要 |
<p>The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1, having selective 2C-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are usefull for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.</p> |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
PASTOR-FERNANDEZ, JOAQUIN;VEGA-RAMIRO, JUAN ANTONIO;DRINKENBURG, WILHELMUS HELENA IGNATIUS MARIA;OYARZABAL SANTAMARINA, JULEN;MARTINEZ GONZALEZ, SONIA;LINARES DE LA MORENA, MARIA LOURDES;DELGADO-JIMENEZ, FRANCISCA;ALCAZAR-VACA, MANUEL JESUS;ANDRES GIL, JOSE IGNACIO |