发明名称 |
Modified 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections |
摘要 |
2' and/or 3' prodrugs of 1', 2', 3' or 4'-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions. |
申请公布号 |
US7547704(B2) |
申请公布日期 |
2009.06.16 |
申请号 |
US20040005467 |
申请日期 |
2004.12.06 |
申请人 |
IDENIX PHARMACEUTICALS, INC.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITA DEGLI STUDI DI CAGLIARI |
发明人 |
LACOLLA PAOLA;STORER RICHARD;GOSSELIN GILLES;SOMMADOSSI JEAN-PIERRE |
分类号 |
A01N43/04;A01N43/54;C07D239/00;C07D239/02 |
主分类号 |
A01N43/04 |
代理机构 |
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