发明名称 (HETERO)ARYL IMIDAZOLES/PYRAZOLES FOR TREATMENT OF NEUROLOGICAL DISORDERS
摘要 The present invention relates to compounds of formula I, wherein A, B, R1, R2, and Z are as defined hereinbefore.;
申请公布号 US2016333018(A1) 申请公布日期 2016.11.17
申请号 US201615220617 申请日期 2016.07.27
申请人 Hoffmann-La Roche Inc. 发明人 Flohr Alexander;Groebke Zbinden Katrin
分类号 C07D487/04 主分类号 C07D487/04
代理机构 代理人
主权项 1. A compound of formula I wherein A is R1 is selected from aryl or heteroaryl, R2 is selected from hydrogen or C1-7 alkyl, R3 is selected from hydrogen or C1-7 alkyl, R4 is selected from hydrogen, C1-7 alkyl, C1-7 alkoxy or C(O)NR′R″, R5 is selected from C1-7 alkyl, C3-8 cycloalkyl, C1-7 haloalkyl, cyano, C1-7 hydroxyalkyl or C(O)NR′R″, R6 is selected from hydrogen, C1-7 alkyl or C1-7 hydroxyalkyl, or R5 and R6 form together C3-8 cycloalkyl, R′ and R″ are in each occurrence independently selected from hydrogen or C1-7 alkyl, X and Y are independently selected from C or N, with the proviso that X and Y are not simultaneously N, Z is selected from CH or N, B is selected from C1-C4-alkylene, C2-C4-alkenylene, C2-C4-alkynylene or —O—C1-C4-alkyl.
地址 Little Falls NJ US