发明名称 |
Phosphorothioate oligonucleotides that bind to the v3-loop and uses thereof |
摘要 |
The present invention provides phosphorothioate oligonucleotide moieties comprising a phosphorothioate oligonucleotide comprising the sequence GmXnGp, wherein G is guanosine; X is thymidine, adenosine or cytidine, or a combination thereof; each of m, n and p is independently an integer greater than 2; the phosphorothioate oligonucleotide moiety being capable of binding to a V3 loop of HIV envelope glycoprotein. The invention further provides for a method of inhibiting HIV activity. The invention also provides for a method of inhibiting HIV activity in a subject. The invention further provides for a method of treating an HIV related disorder in a subject. Finally, the invention provides a pharmaceutical composition comprising a phosphorothioate oligonucleotide moiety and a pharmaceutically acceptable carrier. |
申请公布号 |
AU3212497(A) |
申请公布日期 |
1998.01.05 |
申请号 |
AU19970032124 |
申请日期 |
1997.06.05 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
CY STEIN;SETH LEDERMAN;GREGORY SULLIVAN |
分类号 |
A61K38/00;C07H21/00;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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