发明名称 |
METHOD FOR TREATING A PATIENT AT RISK FOR DEVELOPING AN NSAID-ASSOCIATED ULCER |
摘要 |
The present disclosure is directed to a method for treating a disease or disorder in a patient at risk of developing an NSAID-associated ulcer by administering a pharmaceutical composition in unit dose form comprising naproxen, or pharmaceutically acceptable salt thereof, and esomeprazole, or pharmaceutically acceptable salt thereof. The unit dose is designed to release at least a part of the esomeprazole independent of pH (e.g. at a pH of 0 or more) whereas the naproxen is not released until the pH or the surrounding medium is 3.5 or higher. |
申请公布号 |
CA2764963(C) |
申请公布日期 |
2016.11.01 |
申请号 |
CA20102764963 |
申请日期 |
2010.06.23 |
申请人 |
ASTRAZENECA AB;POZEN INC. |
发明人 |
AULT, BRIAN;HWANG, CLARA;ORLEMANS, EVERARDUS;PLACHETKA, JOHN R.;SOSTEK, MARK |
分类号 |
A61K31/4439;A61K9/24;A61P19/02;A61P29/00 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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