| 摘要 |
The present invention provides a method of treating a subject, in particular a human, suffering from an autoimmune disease. The autoimmune disease is especially preferably but not exclusively selected from systemic lupus erythematosus, multiple sclerosis or 5 rheumatoid arthritis. Said method comprises the step of administering an effective amount of a limonoid to said subject. The present invention further relates to methods of inhibiting the differentiation of T helper 17 cells, T helper 1 cells, T helper 2 cells and/or regulatory T cells and a method of screening substances for their inhibition of one or more of T helper 17 cell, T helper 1 cell, T helper 2 cell and/or regulatory T cell differentiation that may be used to 0 treat an autoimmune disease. The methods of the present invention provide highly advantageous and promising treatment options for autoimmune diseases, namely for attenuating inflammatory lymphocyte function. In particular, the limonoids Amotsangin A, B, C and D are able to suppress T helper 17 (Th17) differentiation with additional inhibitory effect of Amotsangin B and C on the T helper 5 1 cell differentiation, of Amotsangin B, C and D on the T helper 2 cell differentiation and of Amotsangin C on the regulatory T cell differentiation. |
