SYSTEM AND METHOD FOR AUTOMATED GENERATION AND HANDLING OF LIQUID MIXTURES

摘要

The invention relates to a system (1) for supplying a microfluidicsubsystem with liquids, comprising a first valve (14, 29, 46) and a first fluidic duct (10, 25, 28), for connecting said first valve (14, 29, 46) with said microfluidic subsystem and supplying a first liquid, and a second fluidic duct (11), for connecting with said microfluidic subsystem and supplying a second liquid characterized in that said first valve (14, 29, 46) is suitable for closing with time resolution not worse than 100msec, and parameters of said first fluidic duct (10, 15, 28) are chosen such that the value of X1 [Pa-1], defined as: X1 [Pa -1] = (0.5 x 10 -9 +1/E1) (aR12 L12 / A1) is lower than 10 4 Pa-1 where E1 is the Young modulus of the material, of which said first fluidic duct (10, 25, 28) is made, L1 is the length of the said first fluidic duct (10, 25, 28), A1 is the surface area of the lumen of the said first fluidic duct (10, 25, 28) and a R1 is a constant characterizing the geometry of the said first fluidic duct (10, 25, 28) in an equation for the hydraulic resistance R1 of the said first fluidic duct: R1 = aR1 (L1µ / A12 ) with µ denoting the dynamic viscosity coefficient of the fluid filling the said first fluidic duct (10, 25, 28) in the measurement of R1. The invention relates also to a method for producing microdroplets on demand in such a system.