| 摘要 |
Methods for the use of Fc gamma receptor (FcgammaR) polymorphisms as a diagnostic for intervention with interleukin-2 (IL-2) immunotherapy are provided. The methods comprise detecting the allelic pattern of an FcgammaRIIIA gene or FcgammaRIIA gene of an individual, and determining whether the allelic pattern is predictive of a positive therapeutic response to IL-2 immunotherapy. The presence of the FcgammaRIIIA 158F/F homozygous genotype, and/or the presence of one or both copies of the FcgammaRIIIA 48L allele, and/or the presence of one or both copies of the FcgammaRIIA 131R allele is predictive of a positive therapeutic response to IL-2 immunotherapy, and therefore indicative of medical intervention with IL-2 immunotherapy for treatment of an immune disorder. The diagnostic method finds use in identifying those individuals whose immune function can be improved by treatment with IL-2 immunotherapy, particularly for individuals with cancer.
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