RIFAMYCIN ANALOGS AND USES THEREOF

摘要

The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. I n one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3~- hydroxy analogs, 4~-and/or 6~ halo and/or alkoxy analogs, and various 5~ substituents that incorporate a cyclic amine moiety.