COMBINED DNA/PROTEIN VACCINE COMPOSITIONS

摘要

The present invention relates to a novel, combined DNA/Protein antigen vaccine composition comprising nucleic acid molecules and a mineral-based, negatively charged adjuvant, so as to enhance the immungenicity of the DNA vaccine efficiently enhancing not only plasmid DNA vaccines but also providing a novel strategy for immunogenic, multivalent combined protein/DNA vaccine delivery. Preferred adjuvants are aluminium or calcium salts, in particular aluminium phosphate.