Methods for the identification of inhibitors of 1-aminocyclopropane-1-carboxylate oxidase expression or activity in plants

摘要

The present inventors have discovered that 1-Aminocyclopropane-1-Carboxylate Oxidase (ACC) is essential for plant growth. Specifically, the inhibition of ACC gene expression in plant seedlings results in reduced and severely stunted growth, and chlorosis. Thus, ACC can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit ACC expression or activity, comprising: contacting a compound with an ACC and detecting the presence and/or absence of binding between said compound and said an ACC, or detecting a decrease in ACC expression or activity. The methods of the invention are useful for the identification of herbicides.