It is intended to provide a pyrrole-imidazole polyamide type functional molecule having enhanced abilities of alkylating DNA and recognizing a sequence, compared with the existing functional molecules of this type, for a specific base sequence occurring on DNA. A hairpin polyamide having an alkylation site via a vinyl linker at the end of a pyrrole-imidazole polyamide. Drugs for inhibiting the expression of a specific gene and anticancer agents containing the above hairpin polyamide.
申请公布号
WO03076412(A1)
申请公布日期
2003.09.18
申请号
WO2003JP02423
申请日期
2003.03.03
申请人
JAPAN SCIENCE AND TECHNOLOGY CORPORATION;SUGIYAMA, HIROSHI;BANDO, TOSHIKAZU;SAITO, ISAO