A CRYTALLIZED COMPLEX OF AN EUBACTERIUM LARGE RIBOSOME SUBUNIT BOUND TO AN ANTIBIOTIC

摘要

Methods of growing crystals of free, antibiotic complexed, or ribosomal substrate complexed large ribosomal subunits, coordinates defining the three-dimensional atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.