Vaccine formulation active against Mycobacterium tuberculosis bacteria containing a monoglyceride adjuvant

摘要

Vaccine formulation against a mycobacterium comprising, an adjuvant, one or more substances selected from (a) monoglyceride preparations having at least 80% monoglyceride content that has the formula CH2(OR)-CH(OR)-CH2(OR) where R is H or acyl group containing 6 to 24 carbon atoms, provided that two of the R groups are H, and (b) a fatty acid with 6 to 24 carbon atoms, and as immunizing component, an immunogenic product consisting of antigenically active carbohydrate moieties (ACM) derived from Mycobacterium tuberculosis which are each covalently coupled, possibly via identical divalent bridge groups, to immunologically active carriers (IAC).