PIPERAZINE DERIVATIVES AND PRODUCTION METHOD THEREOF

摘要

PURPOSE: A novel piperazine derivative is provided which has excellent anti-cancer effect and low toxity. CONSTITUTION: The piperazine derivatives are shown in a chemical formula(I) wherein R1, R2, R3, R4, R5 and R6 are respectively hydrogen atom, halogen atom, hydroxy radical, nitro radical, amino radical, low class alkyl radical of C1-C4, low class ester radical of C1-C4, unsaturated alkyl radical of substituted or unsubstituted C3-C8, cyclo alkyl radical with substituted or unsubstituted 3-6 rings of C3-C8, low class alkoxy radical of C1-C4, low class thioalkxoy radical of C1-C4 and substituted or unsubstituted low class alkylamino radical. And in the formula, Y is oxygen atom or sulfur atom and Z is hydrogen atom, hydroxy radical, low class alkoxy radical of C1-C8, low class alkyl radical of C1-C4 and low class thioalkoxy radical of C1-C4.