| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1>, R<2>, R<4> and R<6> are H, alkyl, cycloalkyl, aryl, alarkyl, etc.; R<3> and R<5> are H or alkyl; A is formula II (R<4> is H, alkyl, aryl, etc.; Q is 0-5), formula III (R<8> is H, alkyl, aryl, etc.; R<9> is OH, OX, etc.; X is alkyl, aryl, phthalydyl, etc.); m is 0-2; n is 1-5 provided that when R<1> is H, m is O] or salt thereof. EXAMPLE:(2R S, 4S, 5S)-5-[L-N-[(2R)-3-Ethylsulfonyl-2-(1-naphthylmethyl)propionyl]norleuc yl]amino-2-ethyl-4-hydroxy-7-methyl octanoic acid isobutylamide. USE:The compound expressed by formula I has renin-inhibiting action and is useful as a hypotensive agent. PREPARATION:For example, a compound expressed by formula IV is condensed with a compound expressed by formula V to provide the compound expressed by formula I. |
